Of the total drug interactions, 107 are major, 155 are moderate, and 5 are minor
A 50-year-old man with a history of hypertension, hyperlipidemia, and an ischemic cardiomyopathy presents to the emergency department complaining of one-day history of excruciating chest pain, sudden in onset described as sharp and stabbing in nature with exacerbation on deep Concomitant use of colchicine with P-gp inhibitors is contraindicated because life-threatening and fatal colchicine toxicity has been reported in these patients with colchicine taken at therapeutic doses
The prescribing information for colchicine oral solution also references two pharmacokinetic studies showing no significant increase in colchicine levels when co-administered with carvedilol
Before starting colchicine, create an updated list of your medications
The most common DDIs involving colchicine are those mediated by either the cytochrome P450 (CYP450) enzyme and/or the transporter permeability glycoprotein (P-gp)
They are the treatment of choice for most ventricular arrhythmias and a good option for supraventricular arrhythmias, including atrial fibrillation, in patients who are treated with medical therapy
It is a substrate for CYP3A4 and P-glycoprotein (P-gp), and concomitant administration with CYP3A4/P-gp inhibitors can cause life-threatening drug-drug interactions (DDIs) such as pancytopenia, multiorgan failure, and cardiac arrhythmias
1 A DI is defined as the pharmacological or clinical response to the administration or coexposure of a medication with another substance that modifies the patient's Mitigare Interactions
You may need a lower dose of colchicine if you are currently Carvedilol may increase the blood levels of colchicine to dangerous levels, increasing the risk of serious side effects that can affect your muscles, blood cells, nervous system, and multiple organs including the liver and kidneys
See also Warning and Precautions sections
carvedilol + colchicine CV EVENT RISK REDUCTION: contraindicated; GOUT or FMF: contraindicated in pts w/ renal or hepatic impairment; otherwise, decr
6 mg/day divided qd-bid There are 541 drugs known to interact with Coreg (carvedilol), along with 21 disease interactions, and 3 alcohol/food interactions
Applies to: carvedilol and Trelegy Ellipta (fluticasone / umeclidinium / vilanterol) Using carvedilol together with vilanterol may reduce the benefits of both medications, since they have opposing effects in the body
carvedilol will increase the level or effect of colchicine by P-glycoprotein (MDR1) efflux transporter
Anticoagulants • Apixaban cold feeling or numbness in your fingers or toes; chest pain, dry cough, wheezing, chest tightness, trouble breathing; or
You may use the study as a second opinion to make health care decisions
Combining these medications may increase the risk of a rare but serious and potentially fatal condition that affects your muscles and kidneys
Drug-drug Interaction Study of CYP3A4 Inhibitors with Colchicine Oral Solution
Dizziness, lightheadedness, drowsiness, diarrhea, impotence, or tiredness may occur
If you take both medications together, tell your doctor if you have any of these symptoms
The relevance of a particular drug interaction to a specific individual is difficult to determine
It is created by eHealthMe based on reports of 776 people who have interactions when taking Carvedilol and Colchicine from the FDA, and is updated regularly
Colchicine can decrease sperm production Stomach or bowel problems (eg, stomach ulcer)—May increase risk of stomach upset and can make these conditions worse
These classifications are only a guideline
Moderate These classifications are only a guideline
Moderate Drug information provided by: Merative, Micromedex® US Brand Name
Of the total drug interactions, 114 are major, 215 are moderate, and 99 are minor
3 In healthy adults, the mean C max of 2
The relevance of a particular drug interaction to a specific individual is difficult to determine
As intracolonic pressure plays a prominent role in macroscopic perforation of colonic diverticular disease [ 2 ], its augmentation during diarrhea of colchicine's gastrointestinal toxicity may give this drug a predominant causative role
Always consult your healthcare provider before starting or stopping any medication
Effects of carvedilol (blood pressure lowering, reduction in exercise-induced heart rate) are usually seen within 30-60 minutes of administration
Does tamsulosin interact with my other drugs? Enter other medications to view a detailed report
colchicine dose based on indication during and x14 days after carvedilol use as follows: GOUT PROPHYLAXIS: give colchicine 0
The relevance of a particular drug interaction to a specific individual is difficult to determine
There are 691 drugs known to interact with diltiazem, along with 9 disease interactions, and 1 alcohol/food interaction
SETTING AND PRACTICE DESCRIPTION: Relevant to community and institutional pharmacists servicing patients with gout
An
Potential drug–drug interactions with colchicine
Class Antiarrhythmic Substrate drug Precipitant drug Nature of interaction Recommendations; Class IA:
Colchicine can interact with other drugs by a variety of different mechanisms (see Table 2 )
One of the causes of dangerously elevated colchicine concentrations is interaction with other drugs
There are 267 drugs known to interact with Mitigare (colchicine), along with 7 disease interactions, and 1 alcohol/food interaction
There are 541 drugs known to interact with Coreg (carvedilol), along with 21 disease interactions, and 3 alcohol/food interactions
carvedilol + colchicine CV EVENT RISK REDUCTION: contraindicated; GOUT or FMF: contraindicated in pts w/ renal or hepatic impairment; otherwise, decr
Not all beta blockers share this interaction (e
high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss)
Antiarrhythmic drugs (AAD) play an important role in the management of arrhythmias
High blood pressure adds to the workload of the heart and arteries
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in Older adults may be more sensitive to the side effects of this drug, especially muscle weakness /pain and numbness/tingling in their fingers or toes
Combining these medications may increase the risk of a rare but serious and potentially fatal condition that affects your muscles and kidneys
Taking certain heart rhythm Drug-drug Interaction Study of CYP3A4 Inhibitors with Colchicine Oral Solution
Dizziness, lightheadedness, drowsiness, diarrhea, impotence, or tiredness may occur
The risk of serious drug–drug interaction (DDIs) in patients taking colchicine relates to the prescribed dose, the presence of advanced renal or liver disease, and the nature of adjunctive medication
Increased side effects can include serious muscle damage
Avoid combinations; the risk of the interaction outweighs the benefit
Of the total drug interactions, 32 are major, 255 are moderate, and 4 are minor
May make these conditions worse